Nanocarrier-mediated Delivery of CORM-2 Enhances Anti-allodynic and Anti-hyperalgesic Effects of CORM-2.

Joshi, Hari Prasad; Kim, Sung Bum; Kim, Seungki; Kumar, Hemant; Jo, Min-Jae; Choi, Hyemin; Kim, Juri; Kyung, Jae Won; Sohn, Seil; Kim, Kyoung-Tae; Kim, Jin-Ki; Han, In-Bo

Joshi, Hari Prasad; Kim, Sung Bum; Kim, Seungki; Kumar, Hemant; Jo, Min-Jae; Choi, Hyemin; Kim, Juri; Kyung, Jae Won; Sohn, Seil; Kim, Kyoung-Tae; Kim, Jin-Ki; Han, In-Bo.

Afiliação

Joshi HP; Department of Neurosurgery, CHA Bundang Medical Center, School of Medicine, CHA University, 59 Yaptap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.
Kim SB; Department of Neurosurgery, Kyung Hee University, Dongdaemun-gu, Seoul, 02447, Republic of Korea.
Kim S; Department of Surgery, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.
Kumar H; Department of Neurosurgery, CHA Bundang Medical Center, School of Medicine, CHA University, 59 Yaptap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.
Jo MJ; Department of Neurosurgery, CHA Bundang Medical Center, School of Medicine, CHA University, 59 Yaptap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.
Choi H; Department of Neurosurgery, CHA Bundang Medical Center, School of Medicine, CHA University, 59 Yaptap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.
Kim J; Department of Neurosurgery, CHA Bundang Medical Center, School of Medicine, CHA University, 59 Yaptap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.
Kyung JW; Department of Neurosurgery, CHA Bundang Medical Center, School of Medicine, CHA University, 59 Yaptap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.
Sohn S; Department of Neurosurgery, CHA Bundang Medical Center, School of Medicine, CHA University, 59 Yaptap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.
Kim KT; Department of Neurosurgery, School of Medicine, Kyungpook National University, Daegu, South Korea.
Kim JK; Department of Neurosurgery, Kyungpook National University Hospital, Daegu, South Korea.
Han IB; College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, 55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Republic of Korea. jinkikim@hanyang.ac.kr.

Mol Neurobiol ; 56(8): 5539-5554, 2019 Aug.

Article em En | MEDLINE | ID: mdl-30637664

Assuntos

Portadores de Fármacos/química; Hiperalgesia/tratamento farmacológico; Nanopartículas/química; Compostos Organometálicos/uso terapêutico; Animais; Proteínas de Ligação ao Cálcio/metabolismo; Monóxido de Carbono/metabolismo; Feminino; Gânglios Espinais/efeitos dos fármacos; Gânglios Espinais/patologia; Regulação da Expressão Gênica/efeitos dos fármacos; Proteína Glial Fibrilar Ácida/metabolismo; Heme Oxigenase-1/genética; Heme Oxigenase-1/metabolismo; Hiperalgesia/patologia; Interleucina-10/genética; Interleucina-10/metabolismo; Lipídeos/química; Proteínas dos Microfilamentos/metabolismo; Modelos Biológicos; Neuralgia/complicações; Neuralgia/patologia; Óxido Nítrico Sintase Tipo I/genética; Óxido Nítrico Sintase Tipo I/metabolismo; Óxido Nítrico Sintase Tipo II/metabolismo; Compostos Organometálicos/farmacologia; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Ratos Sprague-Dawley; Medula Espinal/patologia; Fator de Necrose Tumoral alfa/genética; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Allodynia; Carbon monoxide; Carbon monoxide releasing molecule; Hyperalgesia; Nanoparticles; Neuropathic pain

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Organometálicos / Portadores de Fármacos / Nanopartículas / Hiperalgesia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Mol Neurobiol Assunto da revista: BIOLOGIA MOLECULAR / NEUROLOGIA Ano de publicação: 2019 Tipo de documento: Article

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