OGTT is recommended for glucose homeostasis assessments in Friedreich ataxia.
Ann Clin Transl Neurol
; 6(1): 161-166, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30656194
ABSTRACT
Diabetes is a common complication of Friedreich ataxia, requiring sensitive diagnostic methods. Here, we compared the performance of different tests that assess glucose tolerance, insulin sensitivity, and ß-cell function in Friedreich ataxia patients, heterozygous FXN mutation carriers and controls. We find that diabetes is underdiagnosed with fasting glucose alone. The oral glucose tolerance test (OGTT) provides 1.2- to 3.5-fold more diagnoses of impaired glucose homeostasis and diabetes, and adequately measures insulin sensitivity, insulin secretion, and ß-cell function. Clinicians in charge of Friedreich ataxia patients and researchers should incorporate the OGTT as an accurate diagnostic and research tool.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicemia
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Ataxia de Friedreich
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Complicações do Diabetes
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Teste de Tolerância a Glucose
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ann Clin Transl Neurol
Ano de publicação:
2019
Tipo de documento:
Article