Peptide Amphiphile Nanostructures for Targeting of Atherosclerotic Plaque and Drug Delivery.
Adv Biosyst
; 2(3)2018 Mar.
Article
em En
| MEDLINE
| ID: mdl-30666317
ABSTRACT
Co-assembled peptide amphiphile nanofibers designed to target atherosclerotic plaque and enhance cholesterol efflux are shown to encapsulate and deliver a liver X receptor agonist to increase efflux from murine macrophages in vitro. Fluorescence microscopy reveals that the nanofibers, which display an apolipoprotein-mimetic peptide, localize at plaque sites in LDL receptor knockout mice with or without the encapsulated molecule, while nanofibers displaying a scrambled, non-targeting peptide sequence do not demonstrate comparable binding. These results show that nanofibers functionalized with apolipoprotein-mimetic peptides may be effective vehicles for intravascular targeted drug delivery to treat atherosclerosis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Adv Biosyst
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos