Double-Stranded RNA Sensors and Modulators in Innate Immunity.
Annu Rev Immunol
; 37: 349-375, 2019 04 26.
Article
em En
| MEDLINE
| ID: mdl-30673536
ABSTRACT
Detection of double-stranded RNAs (dsRNAs) is a central mechanism of innate immune defense in many organisms. We here discuss several families of dsRNA-binding proteins involved in mammalian antiviral innate immunity. These include RIG-I-like receptors, protein kinase R, oligoadenylate synthases, adenosine deaminases acting on RNA, RNA interference systems, and other proteins containing dsRNA-binding domains and helicase domains. Studies suggest that their functions are highly interdependent and that their interdependence could offer keys to understanding the complex regulatory mechanisms for cellular dsRNA homeostasis and antiviral immunity. This review aims to highlight their interconnectivity, as well as their commonalities and differences in their dsRNA recognition mechanisms.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Viroses
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RNA de Cadeia Dupla
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Imunidade Inata
Limite:
Animals
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Humans
Idioma:
En
Revista:
Annu Rev Immunol
Ano de publicação:
2019
Tipo de documento:
Article