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Improved Outcomes With High-dose Isoniazid in Multidrug-resistant Tuberculosis Treatment in Haiti.
Walsh, Kathleen F; Vilbrun, Stalz Charles; Souroutzidis, Ariadne; Delva, Sobieskye; Joissaint, Guy; Mathurin, Laurent; Ocheretina, Oksana; Cremieux, Pierre; Pape, Jean William; Koenig, Serena P.
Afiliação
  • Walsh KF; Center for Global Health, Weill Cornell Medicine, New York City, New York.
  • Vilbrun SC; The Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections, Port-au-Prince, Haiti.
  • Souroutzidis A; Analysis Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  • Delva S; The Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections, Port-au-Prince, Haiti.
  • Joissaint G; The Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections, Port-au-Prince, Haiti.
  • Mathurin L; The Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections, Port-au-Prince, Haiti.
  • Ocheretina O; Center for Global Health, Weill Cornell Medicine, New York City, New York.
  • Cremieux P; Analysis Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  • Pape JW; The Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections, Port-au-Prince, Haiti.
  • Koenig SP; Division of Global Health Equity, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Clin Infect Dis ; 69(4): 717-719, 2019 08 01.
Article em En | MEDLINE | ID: mdl-30698688
We report outcomes for a cohort of patients with multidrug-resistant tuberculosis who received high-dose isoniazid in Haiti. Patients who received high-dose isoniazid had a faster time to culture conversion and higher odds of successful outcome, despite high-level isoniazid resistance. This suggests high-dose isoniazid may have effectiveness even with phenotypic resistance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Resistente a Múltiplos Medicamentos / Isoniazida / Antituberculosos Tipo de estudo: Observational_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Caribe / Haiti Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Resistente a Múltiplos Medicamentos / Isoniazida / Antituberculosos Tipo de estudo: Observational_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Caribe / Haiti Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2019 Tipo de documento: Article