An Emerging Issue in Oncogenic Virology: the Role of Beta Human Papillomavirus Types in the Development of Cutaneous Squamous Cell Carcinoma.
J Virol
; 93(7)2019 04 01.
Article
em En
| MEDLINE
| ID: mdl-30700603
ABSTRACT
Evidence suggests that beta human papillomaviruses (HPVs), together with ultraviolet radiation, contribute to the development of cutaneous squamous cell carcinoma. Beta HPVs appear to be not the main drivers of carcinogenesis but rather facilitators of the accumulation of ultraviolet-induced DNA mutations. Beta HPVs are promoters of skin carcinogenesis, although they are dispensable for the maintenance of the malignant phenotype. Therefore, beta HPV represents a target for skin cancer prevention, especially in high-risk populations.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oncogenes
/
Papillomaviridae
/
Neoplasias Cutâneas
/
Carcinoma de Células Escamosas
/
Infecções por Papillomavirus
/
Carcinogênese
Limite:
Humans
Idioma:
En
Revista:
J Virol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos