Inhibition of bacterial α-, ß- and γ-class carbonic anhydrases with selenazoles incorporating benzenesulfonamide moieties.
J Enzyme Inhib Med Chem
; 34(1): 244-249, 2019 Dec.
Article
em En
| MEDLINE
| ID: mdl-30734601
ABSTRACT
A series of benzenesulfonamides incorporating selenazoles with diverse substitution patterns were investigated as inhibitors of six bacterial carbonic anhydrases (CAs, EC 4.2.1.1) from bacterial pathogens, such as Helicobacter pylori (hpCAα was the investigated enzyme), Vibrio cholerae (all the three CAs from this pathogen were considered, VchCAα, VchCAß and VchCAγ) and Burkholderia pseudomallei (with its two CAs, BpsCAß and BpsCAγ). All these sulfonamides were effective CA inhibitors, with potencies in the low micromolar or submicromolar range, making them attractive as lead compounds for designing antibacterials with a novel mechanism of action, which could counteract the extensive resistance problem observed with many clinically used antibiotics.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
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Vibrio cholerae
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Inibidores da Anidrase Carbônica
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Helicobacter pylori
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Burkholderia pseudomallei
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Compostos Organosselênicos
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Anidrases Carbônicas
Idioma:
En
Revista:
J Enzyme Inhib Med Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Itália