Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision.

Aldunate, Eduardo Zabala; Di Foggia, Valentina; Di Marco, Fabiana; Hervas, Laura Abelleira; Ribeiro, Joana Claudio; Holder, Daniel L; Patel, Aara; Jannini, Tommaso B; Thompson, Dorothy A; Martinez-Barbera, Juan Pedro; Pearson, Rachael A; Ali, Robin R; Sowden, Jane C

Aldunate, Eduardo Zabala; Di Foggia, Valentina; Di Marco, Fabiana; Hervas, Laura Abelleira; Ribeiro, Joana Claudio; Holder, Daniel L; Patel, Aara; Jannini, Tommaso B; Thompson, Dorothy A; Martinez-Barbera, Juan Pedro; Pearson, Rachael A; Ali, Robin R; Sowden, Jane C.

Afiliação

Aldunate EZ; Stem Cells and Regenerative Medicine Section, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
Di Foggia V; Stem Cells and Regenerative Medicine Section, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
Di Marco F; Stem Cells and Regenerative Medicine Section, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
Hervas LA; UCL Institute of Ophthalmology, Department of Genetics, London, 11-43 Bath Street, London, EC1V 9EL, UK.
Ribeiro JC; UCL Institute of Ophthalmology, Department of Genetics, London, 11-43 Bath Street, London, EC1V 9EL, UK.
Holder DL; Stem Cells and Regenerative Medicine Section, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
Patel A; Stem Cells and Regenerative Medicine Section, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
Jannini TB; Stem Cells and Regenerative Medicine Section, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
Thompson DA; Clinical and Academic Department of Ophthalmology Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Martinez-Barbera JP; Developmental Biology of Birth Defects Section, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
Pearson RA; UCL Institute of Ophthalmology, Department of Genetics, London, 11-43 Bath Street, London, EC1V 9EL, UK.
Ali RR; UCL Institute of Ophthalmology, Department of Genetics, London, 11-43 Bath Street, London, EC1V 9EL, UK.
Sowden JC; Stem Cells and Regenerative Medicine Section, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK. j.sowden@ucl.ac.uk.

Sci Rep ; 9(1): 2314, 2019 02 19.

Article em En | MEDLINE | ID: mdl-30783126

Assuntos

Morte Celular/fisiologia; Visão de Cores/fisiologia; RNA Helicases DEAD-box/metabolismo; Integrases/metabolismo; Proteínas do Tecido Nervoso/metabolismo; Receptores Nicotínicos/metabolismo; Células Fotorreceptoras Retinianas Cones/citologia; Células Fotorreceptoras Retinianas Cones/metabolismo; Ribonuclease III/metabolismo; Acuidade Visual/fisiologia; Animais; Morte Celular/genética; Visão de Cores/genética; RNA Helicases DEAD-box/genética; Eletrorretinografia; Feminino; Integrases/genética; Masculino; Camundongos; Camundongos Knockout; Proteínas do Tecido Nervoso/genética; Receptores Nicotínicos/genética; Ribonuclease III/genética; Acuidade Visual/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acuidade Visual / Receptores Nicotínicos / Morte Celular / Células Fotorreceptoras Retinianas Cones / Integrases / Ribonuclease III / RNA Helicases DEAD-box / Visão de Cores / Proteínas do Tecido Nervoso Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido

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