Human cancer, the naked mole rat and faunal turnovers.
Cancer Med
; 8(4): 1652-1654, 2019 04.
Article
em En
| MEDLINE
| ID: mdl-30790458
ABSTRACT
We argue that the human evolutionary heritage with frequent adaptations through geological time to environmental change has affected a trade-off between offspring variability and cancer resistance, and thus favored cancer-prone individuals. We turn the attention to a factor setting the highly cancer-resistant naked mole rat apart from most other mammals it has remained phenotypically largely unchanged since 30-50 million years ago. Research focusing on DNA stability mechanisms in 'living fossil' animals may help us find tools for cancer prevention and treatment.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ratos-Toupeira
/
Suscetibilidade a Doenças
/
Resistência à Doença
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cancer Med
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Suécia