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Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function.
Lumsden, Eric W; Troppoli, Timothy A; Myers, Scott J; Zanos, Panos; Aracava, Yasco; Kehr, Jan; Lovett, Jacqueline; Kim, Sukhan; Wang, Fu-Hua; Schmidt, Staffan; Jenne, Carleigh E; Yuan, Peixiong; Morris, Patrick J; Thomas, Craig J; Zarate, Carlos A; Moaddel, Ruin; Traynelis, Stephen F; Pereira, Edna F R; Thompson, Scott M; Albuquerque, Edson X; Gould, Todd D.
Afiliação
  • Lumsden EW; Department of Epidemiology and Public Health, Division of Translational Toxicology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Troppoli TA; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Myers SJ; Department of Pharmacology, Emory University, Atlanta, GA 30329.
  • Zanos P; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Aracava Y; Department of Epidemiology and Public Health, Division of Translational Toxicology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Kehr J; Department of Physiology and Pharmacology, Karolinska Institute, SE-171 77 Stockholm, Sweden.
  • Lovett J; Pronexus Analytical AB, SE-167 33 Bromma, Sweden.
  • Kim S; Biomedical Research Center, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224.
  • Wang FH; Department of Pharmacology, Emory University, Atlanta, GA 30329.
  • Schmidt S; Department of Physiology and Pharmacology, Karolinska Institute, SE-171 77 Stockholm, Sweden.
  • Jenne CE; Pronexus Analytical AB, SE-167 33 Bromma, Sweden.
  • Yuan P; Department of Physiology and Pharmacology, Karolinska Institute, SE-171 77 Stockholm, Sweden.
  • Morris PJ; Pronexus Analytical AB, SE-167 33 Bromma, Sweden.
  • Thomas CJ; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Zarate CA; Section on the Neurobiology and Treatment of Mood Disorders, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892.
  • Moaddel R; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892.
  • Traynelis SF; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892.
  • Pereira EFR; Section on the Neurobiology and Treatment of Mood Disorders, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892.
  • Thompson SM; Biomedical Research Center, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224.
  • Albuquerque EX; Department of Pharmacology, Emory University, Atlanta, GA 30329.
  • Gould TD; Department of Epidemiology and Public Health, Division of Translational Toxicology, University of Maryland School of Medicine, Baltimore, MD 21201.
Proc Natl Acad Sci U S A ; 116(11): 5160-5169, 2019 03 12.
Article em En | MEDLINE | ID: mdl-30796190
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de N-Metil-D-Aspartato / Ketamina / Antidepressivos Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de N-Metil-D-Aspartato / Ketamina / Antidepressivos Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article