Minimally disseminated disease and outcome in overt orbital retinoblastoma.
Pediatr Blood Cancer
; 66(6): e27662, 2019 06.
Article
em En
| MEDLINE
| ID: mdl-30803140
ABSTRACT
In this retrospective study of patients with overt orbital retinoblastoma, we evaluated minimally disseminated disease (MDD) in bone marrow and cerebrospinal fluid (CSF) using CRX and/or GD2 synthase as markers. Ten patients were evaluated-five (50%) at diagnosis and five upon relapse. MDD was detected in four cases (one in the bone marrow, two in the CSF, and in one case in both sites). All patients received chemotherapy and four received orbital radiotherapy. Seven patients relapsed or progressed and all of them died. Three patients remain in complete remission. There was no apparent correlation between MDD and the outcome.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retinoblastoma
/
Medula Óssea
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Neoplasias Orbitárias
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Protocolos de Quimioterapia Combinada Antineoplásica
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Transativadores
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N-Acetilgalactosaminiltransferases
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Neoplasia Residual
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Proteínas de Homeodomínio
Tipo de estudo:
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Pediatr Blood Cancer
Assunto da revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Argentina