Inhibiting mGluR5 activity by AFQ056/Mavoglurant rescues circuit-specific functional connectivity in Fmr1 knockout mice.

Zerbi, Valerio; Markicevic, Marija; Gasparini, Fabrizio; Schroeter, Aileen; Rudin, Markus; Wenderoth, Nicole

Zerbi, Valerio; Markicevic, Marija; Gasparini, Fabrizio; Schroeter, Aileen; Rudin, Markus; Wenderoth, Nicole.

Afiliação

Zerbi V; Neural Control of Movement Lab, HEST, ETH Zürich, Winterthurerstrasse 190, 8057, Zurich, Switzerland; Neuroscience Center Zurich, University and ETH Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland. Electronic address: valerio.zerbi@hest.ethz.ch.
Markicevic M; Neural Control of Movement Lab, HEST, ETH Zürich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Gasparini F; Novartis Institutes for BioMedical Research, Neuroscience Research, 4002, Basel, Switzerland.
Schroeter A; Institute for Biomedical Engineering, University and ETH Zurich, Wolfgang-Pauli-Str. 27, 8093, Zurich, Switzerland.
Rudin M; Neuroscience Center Zurich, University and ETH Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland; Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland; Institute for Biomedical Engineering, University and ETH Zurich, Wolfgang-Pau
Wenderoth N; Neural Control of Movement Lab, HEST, ETH Zürich, Winterthurerstrasse 190, 8057, Zurich, Switzerland; Neuroscience Center Zurich, University and ETH Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.

Neuroimage ; 191: 392-402, 2019 05 01.

Article em En | MEDLINE | ID: mdl-30807820

Assuntos

Encéfalo/efeitos dos fármacos; Indóis/farmacologia; Vias Neurais/efeitos dos fármacos; Receptor de Glutamato Metabotrópico 5/antagonistas & inibidores; Animais; Encéfalo/metabolismo; Proteína do X Frágil da Deficiência Intelectual/genética; Síndrome do Cromossomo X Frágil; Imageamento por Ressonância Magnética/métodos; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Vias Neurais/metabolismo; Neuroimagem/métodos

Palavras-chave

Autism; Brain connectivity; FMR1; Fragile-X; Resting-state functional MRI; mGluR5

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Receptor de Glutamato Metabotrópico 5 / Indóis / Vias Neurais Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Neuroimage Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2019 Tipo de documento: Article

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