Kidney Safety Assessment: Current Practices in Drug Development.

Troth, Sean P; Simutis, Frank; Friedman, Gary S; Todd, Susan; Sistare, Frank D

Troth, Sean P; Simutis, Frank; Friedman, Gary S; Todd, Susan; Sistare, Frank D.

Afiliação

Troth SP; Merck Research Laboratories, Department of Safety Assessment and Laboratory Animal Resources, West Point, PA. Electronic address: sean_troth@merck.com.
Simutis F; Bristol-Myers Squibb, Drug Safety Evaluation, New Brunswick, NJ.
Friedman GS; Pfizer, Inc, Clinical Development and Operations, Inflammation and Immunology, Collegeville, PA.
Todd S; Pfizer Global Research and Development, Drug Safety Research and Development, Groton, CT.
Sistare FD; Merck Research Laboratories, Department of Safety Assessment and Laboratory Animal Resources, West Point, PA.

Semin Nephrol ; 39(2): 120-131, 2019 Mar.

Article em En | MEDLINE | ID: mdl-30827335

Assuntos

Injúria Renal Aguda/induzido quimicamente; Desenvolvimento de Medicamentos; Insuficiência Renal Crônica/induzido quimicamente; Ensaios Clínicos como Assunto; Humanos; Modelos Animais; Medição de Risco

Palavras-chave

Nephrotoxicity; biomarkers; drug attrition; drug safety; kidney; prediction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Insuficiência Renal Crônica / Injúria Renal Aguda / Desenvolvimento de Medicamentos Tipo de estudo: Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Semin Nephrol Ano de publicação: 2019 Tipo de documento: Article

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