Lipid metabolism genetic risk score interacts with the Brazilian Healthy Eating Index Revised and its components to influence the odds for dyslipidemia in a cross-sectional population-based survey in Brazil.
Nutr Health
; 25(2): 119-126, 2019 Jun.
Article
em En
| MEDLINE
| ID: mdl-30834809
ABSTRACT
BACKGROUND:
Dyslipidemia can be influenced by genetic and dietary risk factors.AIM:
This study set out to investigate diet and genetic variations in Brazilian people in a cross-sectional population-based survey and to analyze the relationship between single nucleotide polymorphisms (SNPs) of genes involved in lipid metabolism and cardiometabolic-related phenotypes using a genetic risk score (GRS).METHODS:
We recruited 228 adults (mean age 36.5 years) who participated in the Health Survey of São Paulo (HS-SP), Brazil. Clinical and anthropometric parameters, as well as the interaction between the GRS and the Brazilian Healthy Eating Index Revised (BHEI-R) were evaluated. We analyzed the relationship between SNPs in APOA5 (rs662799), APOB (rs693, rs1367117), LDLR (rs688, rs5925) and LIPC (rs2070895, rs1800588) and cardiometabolic-related phenotypes using a GRS.RESULTS:
High-density lipoprotein cholesterol (HDLC) levels were associated with the BHEI-R ( p=0.026; ß= -0.183) and with its SoFAAS component (solid fats, alcoholic beverages and added sugars) ( p=0.007; ß=0.279). Non-HDL cholesterol levels were associated with the BHEI-R vegetable component ( p=0.015; ß=0.002) and the meat, eggs and beans component ( p=0.003; ß=0.007). Triacylglycerol levels were associated with the BHEI-R vegetable component ( p=0.027; ß=0.003); the meat, eggs and beans component ( p=0.041; ß=0.001); and the total protein component ( p=0.013; ß=0.032). Significant effects were observed for the interactions between the GRS and both the BHEI-R oils component ( p=0.019) and the SoFAAS component ( p<0.001) on the dyslipidemia risk.CONCLUSIONS:
The evaluation of dietary quality, especially fat quality, together with the lipid metabolism GRS could be a useful tool to manage cardiometabolic risk.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dislipidemias
/
Metabolismo dos Lipídeos
/
Dieta Saudável
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Nutr Health
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Brasil