Plasma concentration and efficacy of tolvaptan in cirrhotic patients with refractory ascites.
J Pharmacol Sci
; 139(4): 373-376, 2019 Apr.
Article
em En
| MEDLINE
| ID: mdl-30857764
ABSTRACT
To investigate the relationship between the exposure and efficacy of tolvaptan, we measured pharmacokinetics of total drug at 7 days after repeated doses of 3.75 mg/day tolvaptan in 16 patients with hepatic edema. Nine patients (56.3%) were responders, which were defined as those with body weight reduction of >1.5 kg/week. Serum albumin levels were significantly lower in responders than in non-responders (P = 0.031). However, the pharmacokinetics varied greatly among individuals and was not relevant to the clinical response.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ascite
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Edema
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Antagonistas dos Receptores de Hormônios Antidiuréticos
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Tolvaptan
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Cirrose Hepática
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Hepatopatias
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Pharmacol Sci
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Japão