JQ1 effectively inhibits vasculogenic mimicry of pancreatic ductal adenocarcinoma cells via the ERK1/2-MMP-2/9 signaling pathway both in vitro and in vivo.

Zhuo, Meng; Yuan, Cuncun; Han, Ting; Hu, Hai; Cui, Jiujie; Jiao, Feng; Wang, Liwei

Zhuo, Meng; Yuan, Cuncun; Han, Ting; Hu, Hai; Cui, Jiujie; Jiao, Feng; Wang, Liwei.

Afiliação

Zhuo M; Department of Oncology, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai Cancer Institute Shanghai 200127, China.
Yuan C; Department of Pathology, Eye & ENT Hospital of Fudan University 83 Fenyang Road, Shanghai 201114, P. R. China.
Han T; Department of Oncology, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai Cancer Institute Shanghai 200127, China.
Hu H; Department of Medical Oncology and Pancreatic Cancer Center, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai, P. R. China.
Cui J; Department of Oncology, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai Cancer Institute Shanghai 200127, China.
Jiao F; Department of Oncology, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai Cancer Institute Shanghai 200127, China.
Wang L; Department of Oncology, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai Cancer Institute Shanghai 200127, China.

Am J Transl Res ; 11(2): 1030-1039, 2019.

Article em En | MEDLINE | ID: mdl-30899402

Palavras-chave

ERK1/2; JQ1; MMP-2/9; Pancreatic ductal adenocarcinoma; vasculogenic mimicry

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Am J Transl Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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