Immunoglobulin allotypes and susceptibility to multiple sclerosis. An epidemiological and genetic study in the Hautes-Pyrénées county of France.
J Neurol Sci
; 75(1): 1-5, 1986 Aug.
Article
em En
| MEDLINE
| ID: mdl-3091773
ABSTRACT
Serum samples collected from 69 patients with multiple sclerosis (MS) living in the Hautes-Pyrénées county were tested for immunoglobulin Gm gamma 1, gamma 2, and gamma 3, heavy chain allotypes (Gm system), and immunoglobulin light chain Kappa (Km system). A control group was made up of normal individuals living in the same county. We found a significant excess of individuals with Gm3; +/- 23;5/Gm3; +/- 23;5 amongst the MS patients as compared with controls (relative risk = 2.4). A slight increase of the Km (1) frequency was found in MS patients compared with controls, 21.7% vs 11.8%, but this difference was not significant.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Frequência do Gene
/
Alótipos de Imunoglobulina
/
Esclerose Múltipla
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Neurol Sci
Ano de publicação:
1986
Tipo de documento:
Article