Mutation of chromatin regulators and focal hotspot alterations characterize human papillomavirus-positive oropharyngeal squamous cell carcinoma.

Haft, Sunny; Ren, Shuling; Xu, Guorong; Mark, Adam; Fisch, Kathleen; Guo, Theresa W; Khan, Zubair; Pang, John; Ando, Mizuo; Liu, Chao; Sakai, Akihiro; Fukusumi, Takahito; Califano, Joseph A

Haft, Sunny; Ren, Shuling; Xu, Guorong; Mark, Adam; Fisch, Kathleen; Guo, Theresa W; Khan, Zubair; Pang, John; Ando, Mizuo; Liu, Chao; Sakai, Akihiro; Fukusumi, Takahito; Califano, Joseph A.

Afiliação

Haft S; Moores Cancer Center, University of California San Diego, La Jolla, California.
Ren S; Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego, La Jolla, California.
Xu G; Moores Cancer Center, University of California San Diego, La Jolla, California.
Mark A; Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego, La Jolla, California.
Fisch K; Moores Cancer Center, University of California San Diego, La Jolla, California.
Guo TW; Center for Computational Biology and Bioinformatics, Department of Medicine, University of California San Diego, La Jolla, California.
Khan Z; Moores Cancer Center, University of California San Diego, La Jolla, California.
Pang J; Center for Computational Biology and Bioinformatics, Department of Medicine, University of California San Diego, La Jolla, California.
Ando M; Moores Cancer Center, University of California San Diego, La Jolla, California.
Liu C; Center for Computational Biology and Bioinformatics, Department of Medicine, University of California San Diego, La Jolla, California.
Sakai A; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Fukusumi T; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Califano JA; Moores Cancer Center, University of California San Diego, La Jolla, California.

Cancer ; 125(14): 2423-2434, 2019 07 15.

Article em En | MEDLINE | ID: mdl-30933315

Assuntos

Montagem e Desmontagem da Cromatina/genética; Papillomavirus Humano 16/imunologia; Mutação; Neoplasias Orofaríngeas/genética; Neoplasias Orofaríngeas/virologia; Infecções por Papillomavirus/genética; Carcinoma de Células Escamosas de Cabeça e Pescoço/genética; Carcinoma de Células Escamosas de Cabeça e Pescoço/virologia; Adulto; Idoso; Classe I de Fosfatidilinositol 3-Quinases/genética; Estudos de Coortes; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Neoplasias Orofaríngeas/patologia; Infecções por Papillomavirus/patologia; Infecções por Papillomavirus/virologia; Receptor Tipo 3 de Fator de Crescimento de Fibroblastos/genética; Carcinoma de Células Escamosas de Cabeça e Pescoço/patologia; Sequenciamento do Exoma

Palavras-chave

The Cancer Genome Atlas (TCGA); epigenetics; exome sequencing; head and neck squamous cell carcinoma; human papillomavirus (HPV); oropharyngeal squamous cell carcinoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Orofaríngeas / Infecções por Papillomavirus / Montagem e Desmontagem da Cromatina / Papillomavirus Humano 16 / Carcinoma de Células Escamosas de Cabeça e Pescoço / Mutação Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Ano de publicação: 2019 Tipo de documento: Article

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