Structures of ligand-occupied ß-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity.

Kuzina, Ekaterina S; Ung, Peter Man-Un; Mohanty, Jyotidarsini; Tome, Francisco; Choi, Jungyuen; Pardon, Els; Steyaert, Jan; Lax, Irit; Schlessinger, Avner; Schlessinger, Joseph; Lee, Sangwon

Kuzina, Ekaterina S; Ung, Peter Man-Un; Mohanty, Jyotidarsini; Tome, Francisco; Choi, Jungyuen; Pardon, Els; Steyaert, Jan; Lax, Irit; Schlessinger, Avner; Schlessinger, Joseph; Lee, Sangwon.

Afiliação

Kuzina ES; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520.
Ung PM; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Mohanty J; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520.
Tome F; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520.
Choi J; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520.
Pardon E; Vlaams Instituut voor Biotechnologie (VIB), Vrije Universiteit Brussel Center for Structural Biology, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Steyaert J; Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Lax I; Vlaams Instituut voor Biotechnologie (VIB), Vrije Universiteit Brussel Center for Structural Biology, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Schlessinger A; Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Schlessinger J; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520.
Lee S; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.

Proc Natl Acad Sci U S A ; 116(16): 7819-7824, 2019 04 16.

Article em En | MEDLINE | ID: mdl-30944224

Assuntos

Fatores de Crescimento de Fibroblastos/química; Fatores de Crescimento de Fibroblastos/metabolismo; Proteínas de Membrana/química; Proteínas de Membrana/metabolismo; Animais; Linhagem Celular; Fator de Crescimento de Fibroblastos 23; Humanos; Proteínas Klotho; Proteínas de Membrana/genética; Modelos Moleculares; Fosforilação; Ligação Proteica; Conformação Proteica; Ratos; Transdução de Sinais/fisiologia; Especificidade por Substrato

Palavras-chave

cell signaling; endocrine FGF; metabolism; phosphorylation; structural biology

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Crescimento de Fibroblastos / Proteínas de Membrana Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article

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