Baicalein attenuates pancreatic inflammatory injury through regulating MAPK, STAT 3 and NF-&#954;B activation.

Pu, Wei-Ling; Bai, Ru-Yu; Zhou, Kun; Peng, Yan-Fei; Zhang, Meng-Ying; Hottiger, Micheal O; Li, Wen-Hua; Gao, Xiu-Mei; Sun, Li-Kang

Baicalein attenuates pancreatic inflammatory injury through regulating MAPK, STAT 3 and NF-κB activation.

Pu, Wei-Ling; Bai, Ru-Yu; Zhou, Kun; Peng, Yan-Fei; Zhang, Meng-Ying; Hottiger, Micheal O; Li, Wen-Hua; Gao, Xiu-Mei; Sun, Li-Kang.

Afiliação

Pu WL; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Bai RY; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Zhou K; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Key Laboratory of Pharmacology of Traditional Chin
Peng YF; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Zhang MY; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Hottiger MO; Department of Molecular Mechanisms of Disease, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Li WH; College of Medicine, Xizang Minzu University (Tibetan National University), Xianyang 712082, Shaanxi, China.
Gao XM; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Key Laboratory of Pharmacology of Traditional Chin
Sun LK; Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. Electronic address: sunlikang_tjutcm@163.com.

Int Immunopharmacol ; 72: 204-210, 2019 Jul.

Article em En | MEDLINE | ID: mdl-30999210

Assuntos

Anti-Inflamatórios; Flavanonas; Proteínas Quinases Ativadas por Mitógeno/metabolismo; NF-kappa B/metabolismo; Pancreatite; Fator de Transcrição STAT3/metabolismo; Células Acinares/efeitos dos fármacos; Células Acinares/metabolismo; Animais; Anti-Inflamatórios/farmacologia; Anti-Inflamatórios/uso terapêutico; Sobrevivência Celular/efeitos dos fármacos; Ceruletídeo; Citocinas/metabolismo; Flavanonas/farmacologia; Flavanonas/uso terapêutico; Camundongos; Camundongos Endogâmicos C57BL; Pâncreas/efeitos dos fármacos; Pâncreas/metabolismo; Pâncreas/patologia; Pancreatite/induzido quimicamente; Pancreatite/tratamento farmacológico; Pancreatite/metabolismo; Pancreatite/patologia; Fitoterapia; Células RAW 264.7; alfa-Amilases/metabolismo

Palavras-chave

Acute pancreatitis; Baicalein; MAPK; NF-κB; STAT 3

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pancreatite / NF-kappa B / Proteínas Quinases Ativadas por Mitógeno / Flavanonas / Fator de Transcrição STAT3 / Anti-Inflamatórios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int Immunopharmacol Assunto da revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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