Dehydrocostus Lactone Suppresses LPS-induced Acute Lung Injury and Macrophage Activation through NF-&#954;B Signaling Pathway Mediated by p38 MAPK and Akt.

Nie, Yunjuan; Wang, Zhongxuan; Chai, Gaoshang; Xiong, Yue; Li, Boyu; Zhang, Hui; Xin, Ruiting; Qian, Xiaohang; Tang, Zihan; Wu, Jiajun; Zhao, Peng

Dehydrocostus Lactone Suppresses LPS-induced Acute Lung Injury and Macrophage Activation through NF-κB Signaling Pathway Mediated by p38 MAPK and Akt.

Nie, Yunjuan; Wang, Zhongxuan; Chai, Gaoshang; Xiong, Yue; Li, Boyu; Zhang, Hui; Xin, Ruiting; Qian, Xiaohang; Tang, Zihan; Wu, Jiajun; Zhao, Peng.

Afiliação

Nie Y; Department of Basic Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, China. nieyunjuan@jiangnan.edu.cn.
Wang Z; Department of Basic Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, China. m18861807206@163.com.
Chai G; Department of Basic Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, China. chaigaoshang@jiangnan.edu.cn.
Xiong Y; Department of Basic Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, China. xiongyyue@163.com.
Li B; Department of Basic Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, China. lby199804@163.com.
Zhang H; Department of Basic Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, China. zhanghui99111@yeah.net.
Xin R; Department of Basic Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, China. 1280116118@vip.jiangnan.edu.cn.
Qian X; Department of Basic Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, China. qianxh@rjlab.cn.
Tang Z; Department of Basic Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, China. 15061885262@163.com.
Wu J; Department of Basic Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, China. orange.jj@foxmail.com.
Zhao P; Department of Basic Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, China. zhaopeng336@jiangnan.edu.cn.

Molecules ; 24(8)2019 Apr 17.

Article em En | MEDLINE | ID: mdl-30999647

Assuntos

Lesão Pulmonar Aguda; Anti-Inflamatórios/farmacologia; Lactonas/farmacologia; Lipopolissacarídeos/toxicidade; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Ativação de Macrófagos/efeitos dos fármacos; Macrófagos/metabolismo; Sesquiterpenos/farmacologia; Lesão Pulmonar Aguda/induzido quimicamente; Lesão Pulmonar Aguda/metabolismo; Lesão Pulmonar Aguda/patologia; Lesão Pulmonar Aguda/prevenção & controle; Animais; Células Cultivadas; Relação Dose-Resposta a Droga; Macrófagos/patologia; Masculino; Camundongos; NF-kappa B/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo

Palavras-chave

Akt; LPS; NF-κB; acute lung injury; dehydrocostus lactone; macrophage; p38MAPK

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Lipopolissacarídeos / Sistema de Sinalização das MAP Quinases / Lesão Pulmonar Aguda / Lactonas / Ativação de Macrófagos / Macrófagos / Anti-Inflamatórios Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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