Cell culture conditions affect the ability of high content imaging assay to detect drug-induced changes in cellular parameters in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs).

Balasubramanian, Bharathi; Belak, Vaclav; Verma, Isha; Prysiazhniuk, Yeva; Sannajust, Frederick; Trepakova, Elena S

Balasubramanian, Bharathi; Belak, Vaclav; Verma, Isha; Prysiazhniuk, Yeva; Sannajust, Frederick; Trepakova, Elena S.

Afiliação

Balasubramanian B; Department of Safety and Exploratory Pharmacology, Safety Assessment and Laboratory Animal Resources, MRL, Merck & Co., Inc, West Point, PA, USA.
Belak V; Deparment of Data Science, MSD Global IT Innovation Center, Prague, Czech Republic.
Verma I; Department of Data Development, Informatics & Analytics, Palo Alto, CA, USA.
Prysiazhniuk Y; Deparment of Data Science, MSD Global IT Innovation Center, Prague, Czech Republic.
Sannajust F; Department of Safety and Exploratory Pharmacology, Safety Assessment and Laboratory Animal Resources, MRL, Merck & Co., Inc, West Point, PA, USA.
Trepakova ES; Department of Safety and Exploratory Pharmacology, Safety Assessment and Laboratory Animal Resources, MRL, Merck & Co., Inc, West Point, PA, USA.

Toxicol Rep ; 6: 305-320, 2019.

Article em En | MEDLINE | ID: mdl-31011540

Palavras-chave

Cell culture; High content imaging; Human induced pluripotent stem cell-derived cardiomyocytes; hiPSC-CMs

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Toxicol Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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