The role of geographical location and climate on recurrent Pseudomonas infection in young children with Cystic Fibrosis.
J Cyst Fibros
; 18(6): 817-822, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-31029605
ABSTRACT
OBJECTIVES:
To determine the association between residence and climate with risk of Pseudomonas aeruginosa (Pa) and other respiratory outcomes.METHODS:
We performed regular bronchoalveolar lavage and upper airway cultures in young children with CF to identify Pa infection. Children were classified for residence as regional or metropolitan. Bronchiectasis was detected on periodic chest computed tomography scans. Multilocus sequence typing determined Pa genotype. Lung function was assessed using Multiple Breath Washout.RESULTS:
Of infants diagnosed with CF between 2006 and 2017, 129 were included in the study. Seven patients moved between metropolitan and regional Victoria and were excluded from analysis. Of the remaining 122 subjects, seventy-four (61%) children resided in metropolitan areas and over half (54%) were male. There were 83â¯Pa episodes in the 122 children who lived consistently in a geographical location. The incidence rate was 0.15 episodes per person-years. We found weak evidence of a 15% increase in the rate of Pa episodes with increasing average annual maximum temperature (95%CI (0.98, 1.36); pâ¯=â¯.086), while the rate of Pa acquision decreased with average annual 3â¯pm humidity (IRRâ¯=â¯0.96; 95%CI(0.92, 1.0008); pâ¯=â¯.054). The rate of Pa episodes was 2.1 times higher in regional participants (95%CI (1.4, 3.1); pâ¯=â¯.001) and risk of second episode was more than five times greater (HR 5.7; 95%CI 1.9, 17); pâ¯=â¯.002). No difference between regions in lung clearance index and presence of bronchiectasis was detected.CONCLUSION:
Regional residence is associated with risk of acquiring recurrent infection with Pseudomonas aeruginosa in young children with CF.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pseudomonas aeruginosa
/
Infecções por Pseudomonas
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Características de Residência
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Clima
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Medição de Risco
/
Fibrose Cística
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Child, preschool
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Female
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Humans
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Infant
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Male
País/Região como assunto:
Oceania
Idioma:
En
Revista:
J Cyst Fibros
Ano de publicação:
2019
Tipo de documento:
Article