RAD18 may function as a predictor of response to preoperative concurrent chemoradiotherapy in patients with locally advanced rectal cancer through caspase-9-caspase-3-dependent apoptotic pathway.

Yan, Xueqi; Chen, Jie; Meng, You; He, Chao; Zou, Shitao; Li, Peng; Chen, Ming; Wu, Jinchang; Ding, Wei-Qun; Zhou, Jundong

Yan, Xueqi; Chen, Jie; Meng, You; He, Chao; Zou, Shitao; Li, Peng; Chen, Ming; Wu, Jinchang; Ding, Wei-Qun; Zhou, Jundong.

Afiliação

Yan X; Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu, PR China.
Chen J; Department of Oncology, The Jiangyin Clinical College of Xuzhou Medical University, Wuxi, Jiangsu, P.R. China.
Meng Y; Department of Surgical Oncology, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu, PR China.
He C; Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu, PR China.
Zou S; Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu, PR China.
Li P; Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu, PR China.
Chen M; Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu, PR China.
Wu J; Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu, PR China.
Ding WQ; Department of Pathology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA.
Zhou J; Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu, PR China.

Cancer Med ; 8(6): 3094-3104, 2019 06.

Article em En | MEDLINE | ID: mdl-31033216

Assuntos

Caspase 3/metabolismo; Caspase 9/metabolismo; Proteínas de Ligação a DNA/biossíntese; Neoplasias Retais/metabolismo; Neoplasias Retais/terapia; Ubiquitina-Proteína Ligases/biossíntese; Animais; Apoptose/efeitos dos fármacos; Apoptose/efeitos da radiação; Linhagem Celular Tumoral; Quimiorradioterapia; Proteínas de Ligação a DNA/genética; Feminino; Células HCT116; Humanos; Imuno-Histoquímica; Camundongos; Camundongos Nus; Pessoa de Meia-Idade; Cuidados Pré-Operatórios/métodos; Neoplasias Retais/genética; Neoplasias Retais/patologia; Transdução de Sinais; Análise de Sobrevida; Transfecção; Resultado do Tratamento; Ubiquitina-Proteína Ligases/genética; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

RAD18; apoptosis; locally advanced rectal cancer; neoadjuvant chemoradiotherapy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retais / Ubiquitina-Proteína Ligases / Proteínas de Ligação a DNA / Caspase 3 / Caspase 9 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Middle aged Idioma: En Revista: Cancer Med Ano de publicação: 2019 Tipo de documento: Article

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