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Mechanistic investigations of the liver toxicity of the free fatty acid receptor 1 agonist fasiglifam (TAK875) and its primary metabolites.
Ackerson, Timothy; Amberg, Alexander; Atzrodt, Jens; Arabeyre, Catherine; Defossa, Elisabeth; Dorau, Martina; Dudda, Angela; Dwyer, Jacquelyn; Holla, Wolfgang; Kissner, Thomas; Kohlmann, Markus; Kürzel, Ulrich; Pánczél, József; Rajanna, Shibani; Riedel, Jens; Schmidt, Friedemann; Wäse, Kerstin; Weitz, Dietmar; Derdau, Volker.
Afiliação
  • Ackerson T; Preclinical Safety, Sanofi, Boston, Massachusetts.
  • Amberg A; Preclinical Safety, Sanofi, Frankfurt, Germany.
  • Atzrodt J; Integrated Drug Discovery, Sanofi, Frankfurt, Germany.
  • Arabeyre C; Biomarkers and Clinical Bioanalysis, Sanofi, Montpellier, France.
  • Defossa E; Integrated Drug Discovery, Sanofi, Frankfurt, Germany.
  • Dorau M; Preclinical Safety, Sanofi, Frankfurt, Germany.
  • Dudda A; Global Project Management Unit, DCV, Sanofi, Frankfurt, Germany.
  • Dwyer J; Preclinical Safety, Sanofi, Boston, Massachusetts.
  • Holla W; Integrated Drug Discovery, Sanofi, Frankfurt, Germany.
  • Kissner T; Preclinical Safety, Sanofi, Frankfurt, Germany.
  • Kohlmann M; Global Project Management Unit, DCV, Sanofi, Frankfurt, Germany.
  • Kürzel U; Drug Metabolism and Pharmacokinetics, Sanofi, Frankfurt, Germany.
  • Pánczél J; Drug Metabolism and Pharmacokinetics, Sanofi, Frankfurt, Germany.
  • Rajanna S; Preclinical Safety, Sanofi, Boston, Massachusetts.
  • Riedel J; Drug Metabolism and Pharmacokinetics, Sanofi, Frankfurt, Germany.
  • Schmidt F; Preclinical Safety, Sanofi, Frankfurt, Germany.
  • Wäse K; Preclinical Safety, Sanofi, Frankfurt, Germany.
  • Weitz D; Drug Metabolism and Pharmacokinetics, Sanofi, Frankfurt, Germany.
  • Derdau V; Integrated Drug Discovery, Sanofi, Frankfurt, Germany.
J Biochem Mol Toxicol ; 33(8): e22345, 2019 Aug.
Article em En | MEDLINE | ID: mdl-31066974
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonas / Benzofuranos / Receptores Acoplados a Proteínas G / Ácidos Graxos não Esterificados / Fígado Limite: Animals / Humans Idioma: En Revista: J Biochem Mol Toxicol Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonas / Benzofuranos / Receptores Acoplados a Proteínas G / Ácidos Graxos não Esterificados / Fígado Limite: Animals / Humans Idioma: En Revista: J Biochem Mol Toxicol Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Ano de publicação: 2019 Tipo de documento: Article