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Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses.
O'Brien, Aisling; Loftus, Roisin M; Pisarska, Marta M; Tobin, Laura M; Bergin, Ronan; Wood, Nicole A W; Foley, Cathriona; Mat, Arimin; Tinley, Frances C; Bannan, Ciaran; Sommerville, Gary; Veerapen, Natacha; Besra, Gurdyal S; Sinclair, Linda V; Moynagh, Paul N; Lynch, Lydia; Finlay, David K; O'Shea, Donal; Hogan, Andrew E.
Afiliação
  • O'Brien A; Obesity Immunology Group, Education and Research Centre, St. Vincent's University Hospital, University College Dublin, Dublin 4, Ireland.
  • Loftus RM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland.
  • Pisarska MM; National Children's Research Centre, Dublin 12, Ireland.
  • Tobin LM; Department of Biology, Institute of Immunology, Maynooth University, Maynooth, County Kildare W23 F2K8, Ireland.
  • Bergin R; Obesity Immunology Group, Education and Research Centre, St. Vincent's University Hospital, University College Dublin, Dublin 4, Ireland.
  • Wood NAW; National Children's Research Centre, Dublin 12, Ireland.
  • Foley C; Department of Biology, Institute of Immunology, Maynooth University, Maynooth, County Kildare W23 F2K8, Ireland.
  • Mat A; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland.
  • Tinley FC; Department of Biology, Institute of Immunology, Maynooth University, Maynooth, County Kildare W23 F2K8, Ireland.
  • Bannan C; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland.
  • Sommerville G; Obesity Immunology Group, Education and Research Centre, St. Vincent's University Hospital, University College Dublin, Dublin 4, Ireland.
  • Veerapen N; Department of Biology, Institute of Immunology, Maynooth University, Maynooth, County Kildare W23 F2K8, Ireland.
  • Besra GS; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland.
  • Sinclair LV; Dana Farber Cancer Institute, Molecular Biology Core Facilities, Boston, MA 02215.
  • Moynagh PN; School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.
  • Lynch L; School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.
  • Finlay DK; Division of Cell Signaling and Immunology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • O'Shea D; Department of Biology, Institute of Immunology, Maynooth University, Maynooth, County Kildare W23 F2K8, Ireland.
  • Hogan AE; School of Medicine, Dentistry and Biomedical Sciences, Wellcome-Wolfson Institute for Experimental Medicine, Queen's University, Belfast BT9 7BL, United Kingdom.
J Immunol ; 202(12): 3404-3411, 2019 06 15.
Article em En | MEDLINE | ID: mdl-31076528
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transportador 1 de Aminoácidos Neutros Grandes / Diabetes Mellitus Tipo 2 / Células T Invariantes Associadas à Mucosa / Alvo Mecanístico do Complexo 1 de Rapamicina / Obesidade Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: J Immunol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Irlanda
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transportador 1 de Aminoácidos Neutros Grandes / Diabetes Mellitus Tipo 2 / Células T Invariantes Associadas à Mucosa / Alvo Mecanístico do Complexo 1 de Rapamicina / Obesidade Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: J Immunol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Irlanda