Characterization of transplant generations of primary rat adenocarcinoma and some chemotherapeutic observations.

ABSTRACT

Rats (Wistar) bearing subcutaneous implants of tumor fragment of DMBA-induced tumor were used in this study. Studies have been made of their proliferative characteristics, and their response to Cis-dichlorodiammine platinum (CDDP) has been measured. The transplanted tumor appears to be on homogeneous solid structure throughout all transplant generations, although the primary site is concomitant adenocarcinoma showing both glandular and solid structure. Microangiography showed that the transplanted tumor was more hypervascular than the primary tumor. Compared with the previous reports using the primary autochthonous tumor, the antitumor effect of CDDP is excellent and the histologic effect is observed in all areas of the sectioned surface. The transplanted tumor could provide a useful experimental system for the laboratory study of the chemotherapy of ovarian adenocarcinoma and the possibility of predicting ovarian adenocarcinoma seemed to be great because of the morphological similarity.