Selective Inhibitors of FKBP51 Employ Conformational Selection of Dynamic Invisible States.

Jagtap, Pravin Kumar Ankush; Asami, Sam; Sippel, Claudia; Kaila, Ville R I; Hausch, Felix; Sattler, Michael

Jagtap, Pravin Kumar Ankush; Asami, Sam; Sippel, Claudia; Kaila, Ville R I; Hausch, Felix; Sattler, Michael.

Afiliação

Jagtap PKA; Lehrstuhl für Biomolekulare NMR-Spektroskopie, Technische Universität München, Lichtenbergstr. 4, 85747, Garching, Germany.
Asami S; Lehrstuhl für Biomolekulare NMR-Spektroskopie, Technische Universität München, Lichtenbergstr. 4, 85747, Garching, Germany.
Sippel C; Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich, Germany.
Kaila VRI; Department Chemie, Technische Universität München, Lichtenbergstr. 4, 85747, Garching, Germany.
Hausch F; Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich, Germany.
Sattler M; Present address: Structure-Based Drug Research, Technische Universität Darmstadt, Alarich-Weiss-Str. 4, 64287, Darmstadt, Germany.

Angew Chem Int Ed Engl ; 58(28): 9429-9433, 2019 07 08.

Article em En | MEDLINE | ID: mdl-31100184

Palavras-chave

FKBP51; NMR spectroscopy; conformational selection; drug selectivity; protein dynamics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha

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