A very potent factor V inhibitor interferes with the levels of all coagulation factors and causes a fatal hemorrhagic syndrome.

Hoffmann, Claire; Amiral, Jean; Rezig, Schéhérazade; Kerspern, Hélène; Jantzem, Hélène; Robin, Sara; Collins, Adam; Mornet, Clelia; Mingant, Fanny; Pan Petesch, Brigitte; Ianotto, Jean-Christophe; Lippert, Eric; Galinat, Hubert

Hoffmann, Claire; Amiral, Jean; Rezig, Schéhérazade; Kerspern, Hélène; Jantzem, Hélène; Robin, Sara; Collins, Adam; Mornet, Clelia; Mingant, Fanny; Pan Petesch, Brigitte; Ianotto, Jean-Christophe; Lippert, Eric; Galinat, Hubert.

Afiliação

Hoffmann C; CHRU Brest - Laboratoire d'Hématologie, Brest, France.
Amiral J; HYPHEN BioMed, Neuville sur Oise, France.
Rezig S; CHRU Brest - Service de Maladies Infectieuses, Brest, France.
Kerspern H; CHRU BREST - Laboratoire de Biochimie, Brest, France.
Jantzem H; CHRU BREST - Pharmacovigilance, Brest, France.
Robin S; CHRU Brest - Service de Médecine Interne, Brest, France.
Collins A; CHRU Brest - Laboratoire d'Hématologie, Brest, France.
Mornet C; CHRU Brest - Laboratoire d'Hématologie, Brest, France.
Mingant F; CHRU Brest - Laboratoire d'Hématologie, Brest, France.
Pan Petesch B; CHRU BREST - Service d'Hématologie Clinique, Brest, France.
Ianotto JC; CHRU BREST - Service d'Hématologie Clinique, Brest, France.
Lippert E; CHRU Brest - Laboratoire d'Hématologie, Brest, France.
Galinat H; Univ Brest, Inserm, EFS, UMR 1078, GGB, Brest, France.

Eur J Haematol ; 103(2): 137-139, 2019 Aug.

Article em En | MEDLINE | ID: mdl-31102471

ABSTRACT

ABSTRACT

We report a very high factor V inhibitor affecting the measurement of all coagulation factors besides fibrinogen, all these factors being dramatically decreased. This inhibitor could be linked to antibiotic use. The patient died of massive hemorrhage before a plasma exchange could be initiated.

Assuntos

Inibidores dos Fatores de Coagulação Sanguínea/sangue; Coagulação Sanguínea; Fator V/antagonistas & inibidores; Hemorragia/sangue; Hemorragia/etiologia; Idoso de 80 Anos ou mais; Biomarcadores; Testes de Coagulação Sanguínea; Suscetibilidade a Doenças; Evolução Fatal; Feminino; Hemorragia/diagnóstico; Humanos

Palavras-chave

coagulation factors; factor V inhibitor; factor inhibitor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Coagulação Sanguínea / Fator V / Inibidores dos Fatores de Coagulação Sanguínea / Hemorragia Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Aged80 / Female / Humans Idioma: En Revista: Eur J Haematol Assunto da revista: HEMATOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: França

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