The Toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liver.

Mescher, Melina; Tigges, Julia; Rolfes, Katharina M; Shen, Anna L; Yee, Jeremiah S; Vogeley, Christian; Krutmann, Jean; Bradfield, Christopher A; Lang, Dieter; Haarmann-Stemmann, Thomas

Mescher, Melina; Tigges, Julia; Rolfes, Katharina M; Shen, Anna L; Yee, Jeremiah S; Vogeley, Christian; Krutmann, Jean; Bradfield, Christopher A; Lang, Dieter; Haarmann-Stemmann, Thomas.

Afiliação

Mescher M; IUF - Leibniz Research Institute for Environmental Medicine, 40225, Düsseldorf, Germany.
Tigges J; IUF - Leibniz Research Institute for Environmental Medicine, 40225, Düsseldorf, Germany.
Rolfes KM; IUF - Leibniz Research Institute for Environmental Medicine, 40225, Düsseldorf, Germany.
Shen AL; The McArdle Laboratory for Cancer Research, Department of Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Yee JS; The McArdle Laboratory for Cancer Research, Department of Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Vogeley C; IUF - Leibniz Research Institute for Environmental Medicine, 40225, Düsseldorf, Germany.
Krutmann J; IUF - Leibniz Research Institute for Environmental Medicine, 40225, Düsseldorf, Germany.
Bradfield CA; Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Lang D; The McArdle Laboratory for Cancer Research, Department of Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Haarmann-Stemmann T; Bayer AG, Pharmaceuticals, DMPK Drug Metabolism, 42096, Wuppertal, Germany.

Arch Toxicol ; 93(7): 1917-1926, 2019 07.

Article em En | MEDLINE | ID: mdl-31111189

Assuntos

Citocromo P-450 CYP1A1/metabolismo; Citocromo P-450 CYP1A2/metabolismo; Imiquimode/metabolismo; Queratinócitos/metabolismo; Adulto; Animais; Antineoplásicos/administração & dosagem; Antineoplásicos/metabolismo; Células Cultivadas; Cromatografia Líquida; Citocromo P-450 CYP1A1/genética; Citocromo P-450 CYP1A2/genética; Relação Dose-Resposta a Droga; Feminino; Humanos; Imiquimode/administração & dosagem; Masculino; Espectrometria de Massas; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Microssomos Hepáticos/metabolismo; Pessoa de Meia-Idade; Receptores de Hidrocarboneto Arílico/metabolismo

Palavras-chave

Aryl hydrocarbon receptor; Cytochrome P450; Imiquimod; Immunotherapy; Psoriasis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Queratinócitos / Citocromo P-450 CYP1A1 / Citocromo P-450 CYP1A2 / Imiquimode Limite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Arch Toxicol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha

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