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Breast cancer outcome prediction with tumour tissue images and machine learning.
Turkki, Riku; Byckhov, Dmitrii; Lundin, Mikael; Isola, Jorma; Nordling, Stig; Kovanen, Panu E; Verrill, Clare; von Smitten, Karl; Joensuu, Heikki; Lundin, Johan; Linder, Nina.
Afiliação
  • Turkki R; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. riku.turkki@helsinki.fi.
  • Byckhov D; Science for Life Laboratory (SciLifeLab), Karolinska Institutet, Solna, Sweden. riku.turkki@helsinki.fi.
  • Lundin M; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
  • Isola J; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
  • Nordling S; Department of Cancer Biology, BioMediTech, University of Tampere, Tampere, Finland.
  • Kovanen PE; Department of Pathology, Medicum, University of Helsinki, Helsinki, Finland.
  • Verrill C; HUSLAB and Medicum, Helsinki University Hospital Cancer Center and University of Helsinki, Helsinki, Finland.
  • von Smitten K; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
  • Joensuu H; NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Lundin J; Eira Hospital, Helsinki, Finland.
  • Linder N; Department of Oncology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Breast Cancer Res Treat ; 177(1): 41-52, 2019 Aug.
Article em En | MEDLINE | ID: mdl-31119567
ABSTRACT

PURPOSE:

Recent advances in machine learning have enabled better understanding of large and complex visual data. Here, we aim to investigate patient outcome prediction with a machine learning method using only an image of tumour sample as an input.

METHODS:

Utilising tissue microarray (TMA) samples obtained from the primary tumour of patients (N = 1299) within a nationwide breast cancer series with long-term-follow-up, we train and validate a machine learning method for patient outcome prediction. The prediction is performed by classifying samples into low or high digital risk score (DRS) groups. The outcome classifier is trained using sample images of 868 patients and evaluated and compared with human expert classification in a test set of 431 patients.

RESULTS:

In univariate survival analysis, the DRS classification resulted in a hazard ratio of 2.10 (95% CI 1.33-3.32, p = 0.001) for breast cancer-specific survival. The DRS classification remained as an independent predictor of breast cancer-specific survival in a multivariate Cox model with a hazard ratio of 2.04 (95% CI 1.20-3.44, p = 0.007). The accuracy (C-index) of the DRS grouping was 0.60 (95% CI 0.55-0.65), as compared to 0.58 (95% CI 0.53-0.63) for human expert predictions based on the same TMA samples.

CONCLUSIONS:

Our findings demonstrate the feasibility of learning prognostic signals in tumour tissue images without domain knowledge. Although further validation is needed, our study suggests that machine learning algorithms can extract prognostically relevant information from tumour histology complementing the currently used prognostic factors in breast cancer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Imuno-Histoquímica / Aprendizado de Máquina Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Breast Cancer Res Treat Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Finlândia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Imuno-Histoquímica / Aprendizado de Máquina Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Breast Cancer Res Treat Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Finlândia