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CYP3A4/5 mediates the metabolic detoxification of humantenmine, a highly toxic alkaloid from Gelsemium elegans Benth.
Sun, Rongjin; Chen, Minghao; Hu, Yanxian; Lan, Yao; Gan, Lili; You, Guoquan; Yue, Min; Wang, Hongmei; Xia, Bijun; Zhao, Jie; Tang, Lan; Cai, Zeng; Liu, Zhongqiu; Ye, Ling.
Afiliação
  • Sun R; Guangdong Provincial Key Laboratory of New Drug Screening, Biopharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
  • Chen M; School of Pharmaceutical Sciences, Hubei University of Medicine, Shiyan, Hubei, China.
  • Hu Y; Guangdong Provincial Key Laboratory of New Drug Screening, Biopharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
  • Lan Y; Center For Certification And Evaluation, Guangdong Food And Drug Administration, Guangzhou, China.
  • Gan L; Guangdong Provincial Key Laboratory of New Drug Screening, Biopharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
  • You G; Guangdong Provincial Key Laboratory of New Drug Screening, Biopharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
  • Yue M; Guangdong Provincial Key Laboratory of New Drug Screening, Biopharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
  • Wang H; Department of Laboratory Animal Center, Southern Medical University, Guangzhou, China.
  • Xia B; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Zhao J; Guangdong Provincial Key Laboratory of New Drug Screening, Biopharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
  • Tang L; Guangdong Provincial Key Laboratory of New Drug Screening, Biopharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
  • Cai Z; Guangdong Provincial Key Laboratory of New Drug Screening, Biopharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
  • Liu Z; Guangdong Provincial Key Laboratory of New Drug Screening, Biopharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
  • Ye L; Guangdong Provincial Key Laboratory of New Drug Screening, Biopharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
J Appl Toxicol ; 39(9): 1283-1292, 2019 09.
Article em En | MEDLINE | ID: mdl-31119768
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microssomos Hepáticos / Inativação Metabólica / Sistema Enzimático do Citocromo P-450 / Gelsemium / Alcaloides Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: J Appl Toxicol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microssomos Hepáticos / Inativação Metabólica / Sistema Enzimático do Citocromo P-450 / Gelsemium / Alcaloides Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: J Appl Toxicol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China