A Higher Mediterranean Diet Score, Including Unprocessed Red Meat, Is Associated with Reduced Risk of Central Nervous System Demyelination in a Case-Control Study of Australian Adults.
J Nutr
; 149(8): 1385-1392, 2019 08 01.
Article
em En
| MEDLINE
| ID: mdl-31131415
ABSTRACT
BACKGROUND:
The evidence associating diet and risk of multiple sclerosis (MS) is inconclusive.OBJECTIVES:
The aim of this study was to investigate associations between a Mediterranean diet and risk of a first clinical diagnosis of central nervous system demyelination (FCD), a common precursor to MS.METHODS:
We used data from the 2003-2006 Ausimmune Study, an Australian multicenter, case-control study examining environmental risk factors for FCD, with participants matched on age, sex, and study region (282 cases, 558 controls; 18-59 y old; 78% female). The alternate Mediterranean diet score (aMED) was calculated based on data from a food-frequency questionnaire. We created a modified version of the aMED (aMED-Red) where â¼1 daily serving (65 g) of unprocessed red meat received 1 point. All other components remained the same as aMED. Conditional logistic regression (254 cases, 451 controls) was used to test associations between aMED and aMED-Red scores and categories and risk of FCD, adjusting for history of infectious mononucleosis, serum 25-hydroxyvitamin D concentrations, smoking, education, total energy intake, and dietary underreporting.RESULTS:
There was no statistically significant association between aMED and risk of FCD [per 1-SD increase in aMED score adjusted odds ratio (aOR) 0.89; 95% CI 0.75, 1.06; P = 0.181]. There was evidence of a nonlinear relation between aMED-Red and risk of FCD when a quadratic term was used (P = 0.016). Compared with the lowest category of aMED-Red, higher categories were significantly associated with reduced risk of FCD, corresponding to a 37% (aOR 0.63; 95% CI 0.41, 0.98; P = 0.039), 52% (aOR 0.48; 95% CI 0.28, 0.83; P = 0.009), and 42% (aOR 0.58; 95% CI 0.35, 0.96; P = 0.034) reduced risk of FCD in categories 2, 3, and 4, respectively.CONCLUSIONS:
A Mediterranean diet, including unprocessed red meat, was associated with reduced risk of FCD in this Australian adult population. The addition of unprocessed red meat to a Mediterranean diet may be beneficial for those at high risk of MS.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças do Sistema Nervoso Central
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Doenças Desmielinizantes
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Dieta Mediterrânea
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Carne Vermelha
Tipo de estudo:
Clinical_trials
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Etiology_studies
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Observational_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Oceania
Idioma:
En
Revista:
J Nutr
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Austrália