Immunochemical characterization and quantification of the sex steroid-binding protein (SBP) in human amniotic fluid.
Clin Chim Acta
; 167(1): 43-9, 1987 Jul 30.
Article
em En
| MEDLINE
| ID: mdl-3117438
ABSTRACT
The sex steroid-binding protein (SBP) is a plasma protein whose concentration in the maternal circulation increases during pregnancy. Using monospecific antibodies raised against human SBP, we could demonstrate the antigenic identity of the protein in human amniotic fluid. In this fluid, we found that the SBP concentration was correlated with the total protein concentration throughout gestation. The concentration gradient of SBP between maternal serum and amniotic fluid was compared to that of other serum proteins, in relation to their relative molecular mass, and it was concluded that SBP enters amniotic fluid in a non-specific manner similar to that of other serum proteins. It is suggested that SBP could act to sequester the sex steroid hormones in amniotic fluid.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Transporte
/
Líquido Amniótico
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Clin Chim Acta
Ano de publicação:
1987
Tipo de documento:
Article
País de afiliação:
França