Mechanical strain, novel genes and evolutionary insights: news from the frog left-right organizer.
Curr Opin Genet Dev
; 56: 8-14, 2019 06.
Article
em En
| MEDLINE
| ID: mdl-31185381
ABSTRACT
Animal asymmetries are widespread, from lobster claws to human handedness. Controlled by the left-sided Nodal signaling cascade, asymmetric morphogenesis and placement of vertebrate organs (heart, gut, etc.) are executed during embryogenesis. Fish, amphibians and mammals use a ciliated epithelium to break bilateral symmetry and induce the Nodal cascade. Cilia tilt and polarize to the posterior cell pole, such that clockwise rotation causes a leftward flow at the cell surface. Recent progress in Xenopus showed that mechanical strain drives cilia lengthening and polarization. Studying mutant alleles causing human organ situs defects and following novel EvoDevo approaches, new genes were discovered and functionally characterized in the frog, facilitated by a unique set of experimental tools.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Xenopus laevis
/
Regulação da Expressão Gênica no Desenvolvimento
/
Padronização Corporal
/
Desenvolvimento Embrionário
Limite:
Animals
Idioma:
En
Revista:
Curr Opin Genet Dev
Assunto da revista:
GENETICA
Ano de publicação:
2019
Tipo de documento:
Article