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Betulin and its derivatives as novel compounds with different pharmacological effects.
Amiri, Shayan; Dastghaib, Sanaz; Ahmadi, Mazaher; Mehrbod, Parvaneh; Khadem, Forough; Behrouj, Hamid; Aghanoori, Mohamad-Reza; Machaj, Filip; Ghamsari, Mahdi; Rosik, Jakub; Hudecki, Andrzej; Afkhami, Abbas; Hashemi, Mohammad; Los, Marek J; Mokarram, Pooneh; Madrakian, Tayyebeh; Ghavami, Saeid.
Afiliação
  • Amiri S; Department of Human Anatomy and Cell Science, Rady College of Medicine, Max Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
  • Dastghaib S; Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Ahmadi M; Department of Analytical Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.
  • Mehrbod P; Influenza and Respiratory Viruses Department, Pasteur Institute of IRAN, Tehran, Iran.
  • Khadem F; Department of Immunology, Rady College of Medicine, Max Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
  • Behrouj H; Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Aghanoori MR; Division of Neurodegenerative Disorders, St Boniface Hospital Albrechtsen Research Centre, Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada.
  • Machaj F; Department of Pathology, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-344 Szczecin, Poland.
  • Ghamsari M; Department of Analytical Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.
  • Rosik J; Department of Pathology, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-344 Szczecin, Poland.
  • Hudecki A; Institue of Non-Ferrous Metals, ul. Sowinskiego 5, 44-100 Gliwice, Poland.
  • Afkhami A; Department of Analytical Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.
  • Hashemi M; Department of Clinical Biochemistry, Zahedan University of Medical Science, Zahedan, Iran.
  • Los MJ; Biotechnology Center, Silesian University of Technology, ul Boleslawa Krzywoustego 8, Gliwice, Poland; Linkocare Life Sciences AB, Teknikringen 10, Plan 3, 583 30 Linköping, Sweden.
  • Mokarram P; Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Madrakian T; Department of Analytical Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.
  • Ghavami S; Department of Human Anatomy and Cell Science, Rady College of Medicine, Max Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Biology of Breathing Theme, Children Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Canada; Health Policy Research Center
Biotechnol Adv ; 38: 107409, 2020.
Article em En | MEDLINE | ID: mdl-31220568
ABSTRACT
Betulin (B) and Betulinic acid (BA) are natural pentacyclic lupane-structure triterpenoids which possess a wide range of pharmacological activities. Recent evidence indicates that B and BA have several properties useful for the treatment of metabolic disorders, infectious diseases, cardiovascular disorders, and neurological disorders. In the current review, we discuss B and BA structures and derivatives and then comprehensively explain their pharmacological effects in relation to various diseases. We also explain antiviral, antibacterial and anti-cancer effects of B and BA. Finally, we discuss the delivery methods, in which these compounds most effectively target different systems.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos Idioma: En Revista: Biotechnol Adv Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos Idioma: En Revista: Biotechnol Adv Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Canadá