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Synthetic Flavonoids as Novel Modulators of Platelet Function and Thrombosis.
Vallance, Thomas M; Ravishankar, Divyashree; Albadawi, Dina A I; Osborn, Helen M I; Vaiyapuri, Sakthivel.
Afiliação
  • Vallance TM; School of Pharmacy, University of Reading, Whiteknights, Reading RG6 6UB, UK. t.m.vallance@pgr.reading.ac.uk.
  • Ravishankar D; School of Pharmacy, University of Reading, Whiteknights, Reading RG6 6UB, UK. divyasri.april86@gmail.com.
  • Albadawi DAI; School of Pharmacy, University of Reading, Whiteknights, Reading RG6 6UB, UK. d.a.i.albadawi@pgr.reading.ac.uk.
  • Osborn HMI; School of Pharmacy, University of Reading, Whiteknights, Reading RG6 6UB, UK. h.m.i.osborn@reading.ac.uk.
  • Vaiyapuri S; School of Pharmacy, University of Reading, Whiteknights, Reading RG6 6UB, UK. s.vaiyapuri@reading.ac.uk.
Int J Mol Sci ; 20(12)2019 Jun 25.
Article em En | MEDLINE | ID: mdl-31242657
ABSTRACT
Cardiovascular diseases represent a major cause of mortality and morbidity in the world, and specifically, thrombotic conditions such as heart attacks and strokes are caused by unwarranted activation of platelets and subsequent formation of blood clots (thrombi) within the blood vessels during pathological circumstances. Therefore, platelets act as a primary therapeutic target to treat and prevent thrombotic conditions. Current treatments are limited due to intolerance, and they are associated with severe side effects such as bleeding complications. Hence, the development of novel therapeutic strategies for thrombotic diseases is an urgent priority. Flavonoids are naturally occurring plant-derived molecules that exert numerous beneficial effects in humans through modulating the functions of distinct cell types. However, naturally occurring flavonoids suffer from several issues such as poor solubility, lipophilicity, and bioavailability, which hinder their efficacy and potency. Despite these, flavonoids act as versatile templates for the design and synthesis of novel molecules for various therapeutic targets. Indeed, several synthetic flavonoids have recently been developed to improve their stability, bioavailability, and efficacy, including for the modulation of platelet function. Here, we provide insight into the actions of certain natural flavonoids along with the advantages of synthetic flavonoids in the modulation of platelet function, haemostasis, and thrombosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose / Flavonoides / Plaquetas Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose / Flavonoides / Plaquetas Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido