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(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase.
Rageot, Denise; Bohnacker, Thomas; Keles, Erhan; McPhail, Jacob A; Hoffmann, Reece M; Melone, Anna; Borsari, Chiara; Sriramaratnam, Rohitha; Sele, Alexander M; Beaufils, Florent; Hebeisen, Paul; Fabbro, Doriano; Hillmann, Petra; Burke, John E; Wymann, Matthias P.
Afiliação
  • Rageot D; Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.
  • Bohnacker T; Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.
  • Keles E; Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.
  • McPhail JA; Department of Biochemistry and Microbiology , University of Victoria , Victoria , British Columbia V8W 2Y2 , Canada.
  • Hoffmann RM; Department of Biochemistry and Microbiology , University of Victoria , Victoria , British Columbia V8W 2Y2 , Canada.
  • Melone A; Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.
  • Borsari C; Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.
  • Sriramaratnam R; Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.
  • Sele AM; Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.
  • Beaufils F; Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.
  • Hebeisen P; PIQUR Therapeutics AG , Hochbergerstrasse 60C , 4057 Basel , Switzerland.
  • Fabbro D; PIQUR Therapeutics AG , Hochbergerstrasse 60C , 4057 Basel , Switzerland.
  • Hillmann P; PIQUR Therapeutics AG , Hochbergerstrasse 60C , 4057 Basel , Switzerland.
  • Burke JE; Department of Biochemistry and Microbiology , University of Victoria , Victoria , British Columbia V8W 2Y2 , Canada.
  • Wymann MP; Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.
J Med Chem ; 62(13): 6241-6261, 2019 07 11.
Article em En | MEDLINE | ID: mdl-31244112
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Triazinas / Morfolinas / Fosfatidilinositol 3-Quinases / Serina-Treonina Quinases TOR / Inibidores de Fosfoinositídeo-3 Quinase / Aminopiridinas / Antineoplásicos Limite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Suíça
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Triazinas / Morfolinas / Fosfatidilinositol 3-Quinases / Serina-Treonina Quinases TOR / Inibidores de Fosfoinositídeo-3 Quinase / Aminopiridinas / Antineoplásicos Limite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Suíça