MicroRNAs as Biomarkers for Germ Cell Tumors.
Urol Clin North Am
; 46(3): 449-457, 2019 Aug.
Article
em En
| MEDLINE
| ID: mdl-31277739
ABSTRACT
Two clusters of microRNAs have been discovered highly expressed by seminoma and nonseminoma germ cell tumors. They are secreted in blood of patients with testicular germ cell tumors and can be extracted from the serum or plasma and quantified by real-time-polymerase chain reaction. Results have confirmed the feasibility of the technique and demonstrated that sensitivity and specificity of those microRNAs in detecting viable germ cell tumors are higher than with current methods. If operation characteristics are confirmed in larger studies, those microRNAs will be valuable to manage equivocal clinical scenarios characterized by high uncertainty and high risk of over-treatment or under-treatment.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Testiculares
/
Biomarcadores Tumorais
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Neoplasias Embrionárias de Células Germinativas
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MicroRNAs
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
/
Male
Idioma:
En
Revista:
Urol Clin North Am
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Canadá