Development of an underivatized LC-MS/MS method for quantitation of 14 neurotransmitters in rat hippocampus, plasma and urine: Application to CUMS induced depression rats.

Han, Xue-Mei; Qin, Yan-Jie; Zhu, Ying; Zhang, Xin-Lin; Wang, Nan-Xi; Rang, Ying; Zhai, Xue-Jia; Lu, Yong-Ning

Han, Xue-Mei; Qin, Yan-Jie; Zhu, Ying; Zhang, Xin-Lin; Wang, Nan-Xi; Rang, Ying; Zhai, Xue-Jia; Lu, Yong-Ning.

Afiliação

Han XM; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Qin YJ; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Zhu Y; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Zhang XL; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Wang NX; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Rang Y; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Zhai XJ; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address: zhaixuejia@163.com.
Lu YN; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address: luyn_union@163.com.

J Pharm Biomed Anal ; 174: 683-695, 2019 Sep 10.

Article em En | MEDLINE | ID: mdl-31288191

Assuntos

Cromatografia Líquida/métodos; Depressão/sangue; Depressão/urina; Hipocampo/química; Neurotransmissores/análise; Neurotransmissores/sangue; Neurotransmissores/urina; Espectrometria de Massas em Tandem/métodos; Animais; Análise Química do Sangue; Modelos Animais de Doenças; Ácido Glutâmico/metabolismo; Ácido Cinurênico/sangue; Cinurenina/metabolismo; Limite de Detecção; Modelos Lineares; Masculino; Fenilalanina/metabolismo; Ratos; Ratos Sprague-Dawley; Reprodutibilidade dos Testes; Triptofano/metabolismo; Urinálise

Palavras-chave

Chronic unpredictable mild stress; Glutamate metabolism; Liquid chromatographytandem mass spectrometry; Phenylalanine metabolism; Tryptophan metabolism

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromatografia Líquida / Neurotransmissores / Depressão / Espectrometria de Massas em Tandem / Hipocampo Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Pharm Biomed Anal Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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