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Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer.
Nguyen, Paul M; Dagley, Laura F; Preaudet, Adele; Lam, Nga; Giam, Maybelline; Fung, Ka Yee; Aizel, Kaheina; van Duijneveldt, Gemma; Tan, Chin Wee; Hirokawa, Yumiko; Yip, Hon Yan K; Love, Christopher G; Poh, Ashleigh R; Cruz, Akshay D'; Burstroem, Charlotte; Feltham, Rebecca; Abdirahman, Suad M; Meiselbach, Kristy; Low, Ronnie Ren Jie; Palmieri, Michelle; Ernst, Matthias; Webb, Andrew I; Burgess, Tony; Sieber, Oliver M; Bouillet, Philippe; Putoczki, Tracy L.
Afiliação
  • Nguyen PM; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Dagley LF; The Department of Medical Biology, The University of Melbourne, Melbourne, VIC, 3050, Australia.
  • Preaudet A; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Lam N; The Department of Medical Biology, The University of Melbourne, Melbourne, VIC, 3050, Australia.
  • Giam M; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Fung KY; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Aizel K; The Department of Medical Biology, The University of Melbourne, Melbourne, VIC, 3050, Australia.
  • van Duijneveldt G; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Tan CW; The Department of Medical Biology, The University of Melbourne, Melbourne, VIC, 3050, Australia.
  • Hirokawa Y; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Yip HYK; The Department of Medical Biology, The University of Melbourne, Melbourne, VIC, 3050, Australia.
  • Love CG; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Poh AR; The Department of Medical Biology, The University of Melbourne, Melbourne, VIC, 3050, Australia.
  • Cruz A; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Burstroem C; The Department of Medical Biology, The University of Melbourne, Melbourne, VIC, 3050, Australia.
  • Feltham R; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Abdirahman SM; The Department of Medical Biology, The University of Melbourne, Melbourne, VIC, 3050, Australia.
  • Meiselbach K; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Low RRJ; The Department of Medical Biology, The University of Melbourne, Melbourne, VIC, 3050, Australia.
  • Palmieri M; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Ernst M; Now located at Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, 3800, Australia.
  • Webb AI; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Burgess T; The Department of Medical Biology, The University of Melbourne, Melbourne, VIC, 3050, Australia.
  • Sieber OM; Research Division, Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, Australia.
  • Bouillet P; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Putoczki TL; The Department of Medical Biology, The University of Melbourne, Melbourne, VIC, 3050, Australia.
Cell Death Differ ; 27(2): 742-757, 2020 02.
Article em En | MEDLINE | ID: mdl-31296963
ABSTRACT
Gastrointestinal epithelial cells provide a selective barrier that segregates the host immune system from luminal microorganisms, thereby contributing directly to the regulation of homeostasis. We have shown that from early embryonic development Bcl-G, a Bcl-2 protein family member with unknown function, was highly expressed in gastrointestinal epithelial cells. While Bcl-G was dispensable for normal growth and development in mice, the loss of Bcl-G resulted in accelerated progression of colitis-associated cancer. A label-free quantitative proteomics approach revealed that Bcl-G may contribute to the stability of a mucin network, which when disrupted, is linked to colon tumorigenesis. Consistent with this, we observed a significant reduction in Bcl-G expression in human colorectal tumors. Our study identifies an unappreciated role for Bcl-G in colon cancer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Proteínas Proto-Oncogênicas c-bcl-2 / Inflamação Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Cell Death Differ Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Proteínas Proto-Oncogênicas c-bcl-2 / Inflamação Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Cell Death Differ Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália