Do Astrocytes Play a Role in Intellectual Disabilities?
Trends Neurosci
; 42(8): 518-527, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-31300246
ABSTRACT
Neurodevelopmental disorders, including those involving intellectual disability, are characterized by abnormalities in formation and functions of synaptic circuits. Traditionally, research on synaptogenesis and synaptic transmission in health and disease focused on neurons, however, a growing number of studies have highlighted the role of astrocytes in this context. Tight structural and functional interactions of astrocytes and synapses indeed play important roles in brain functions, and the repertoire of astroglial regulations of synaptic circuits is large and complex. Recently, genetic studies of intellectual disabilities have underscored potential contributions of astrocytes in the pathophysiology of these disorders. Here we review how alterations of astrocyte functions in disease may interfere with neuronal excitability and the balance of excitatory and inhibitory transmission during development, and contribute to intellectual disabilities.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Astrócitos
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Deficiência Intelectual
Limite:
Animals
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Humans
Idioma:
En
Revista:
Trends Neurosci
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
França