<i>N</i>-Glycosylation regulates ligand-dependent activation and signaling of vascular endothelial growth factor receptor 2 (VEGFR2).

Chandler, Kevin Brown; Leon, Deborah R; Kuang, Jenevieve; Meyer, Rosana D; Rahimi, Nader; Costello, Catherine E

N-Glycosylation regulates ligand-dependent activation and signaling of vascular endothelial growth factor receptor 2 (VEGFR2).

Chandler, Kevin Brown; Leon, Deborah R; Kuang, Jenevieve; Meyer, Rosana D; Rahimi, Nader; Costello, Catherine E.

Afiliação

Chandler KB; Center for Biomedical Mass Spectrometry, Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118.
Leon DR; Center for Biomedical Mass Spectrometry, Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118.
Kuang J; Center for Biomedical Mass Spectrometry, Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118; Department of Chemistry, Boston University, Boston, Massachusetts 02118.
Meyer RD; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston Massachusetts 02118.
Rahimi N; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston Massachusetts 02118.
Costello CE; Center for Biomedical Mass Spectrometry, Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118; Department of Chemistry, Boston University, Boston, Massachusetts 02118. Electronic address: cecmsms@bu.edu.

J Biol Chem ; 294(35): 13117-13130, 2019 08 30.

Article em En | MEDLINE | ID: mdl-31308178

Assuntos

Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo; Linhagem Celular; Glicosilação; Células Endoteliais da Veia Umbilical Humana/metabolismo; Humanos; Ligantes; Polissacarídeos/química; Polissacarídeos/metabolismo; Transdução de Sinais; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/química

Palavras-chave

N-glycan; N-linked glycosylation; angiogenesis; angiogenic signaling; cytokine signaling; endothelial cell; endothelial signaling; glycosylation; receptor tyrosine kinase; sialic acid; vascular endothelial growth factor (VEGF); vascular endothelial growth factor receptor 2 (VEGFR2)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor 2 de Fatores de Crescimento do Endotélio Vascular Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article

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