mTOR as a central regulator of lifespan and aging.
F1000Res
; 82019.
Article
em En
| MEDLINE
| ID: mdl-31316753
ABSTRACT
The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and proliferation. Although the involvement of the mTOR pathway in regulating life span and aging has been studied extensively in the last decade, the underpinning mechanisms remain elusive. In this review, we highlight the emerging insights that link mTOR to various processes related to aging, such as nutrient sensing, maintenance of proteostasis, autophagy, mitochondrial dysfunction, cellular senescence, and decline in stem cell function.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Envelhecimento
/
Senescência Celular
/
Serina-Treonina Quinases TOR
/
Longevidade
Limite:
Animals
Idioma:
En
Revista:
F1000Res
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Canadá