Long noncoding RNA00887 reduces the invasion and metastasis of nonsmall cell lung cancer by causing the degradation of miRNAs.
Oncol Rep
; 42(3): 1173-1182, 2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-31322230
ABSTRACT
Long noncoding RNAs (lncRNAs) can act as carcinogenic or cancer suppressive factors during the pathogenesis, invasion and metastasis of nonsmall cell lung cancer (NSCLC). The current study explored the role of long intergenic nonprotein coding RNA 00887 (LINC00887) and competing endogenous RNAs (ceRNAs). It was revealed that LINC00887 interacts with several microRNAs (miRs), which regulates downstream genes such as fibronectin 1, MET protooncogene, receptor tyrosine kinase and mothers against decapentaplegic homolog 4, which are associated with the spread of lung cancer. The experimental results also suggested that LINC00887 can stimulate miR613, miR206 and miR12 to become competing endogenous RNAs, which may regulate the epithelialmesenchymal transition of NSCLC cells through the transforming growth factorâ signal transduction pathway, and therefore promote the migration of cells and the acquisition of stem cell characteristics. Therefore, it can be concluded that high levels of LINC00887 can accelerate the malignant transformation ability of NSCLC cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores Tumorais
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Movimento Celular
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Carcinoma Pulmonar de Células não Pequenas
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MicroRNAs
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RNA Longo não Codificante
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Adenocarcinoma de Pulmão
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Neoplasias Pulmonares
Limite:
Humans
Idioma:
En
Revista:
Oncol Rep
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2019
Tipo de documento:
Article