Oridonin enhances TRAIL-induced apoptosis through GALNT14-mediated DR5 glycosylation.
Biochimie
; 165: 108-114, 2019 Oct.
Article
em En
| MEDLINE
| ID: mdl-31336136
ABSTRACT
Oridonin is a diterpenoid isolated from the Rabdosia rubescens and has multiple biological effects, such as anti-inflammation and anti-tumor activities. In present study, we revealed that the sensitizing effect of oridonin on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in several cancer cells, but not in normal cells. Oridonin enhanced death-signaling inducing complexes (DISC) formation and DR5 glycosylation without affecting expression of downstream intracellular apoptosis-related proteins. Oridonin upregulated peptidyl O-glycosyltransferase GALNT14 in a dose- and time-dependent manner. Knockdown of GALNT14 by siRNA and Endo H treatment reduced oridonin-induced DR5 glycosylation. Furthermore, treatment with inhibitor of glycosylation (benzyl-α-GalNAc) blocked oridonin plus TRAIL-induced apoptosis. Collectively, our results suggest that oridonin-induced DR5 glycosylation contributes to TRAIL-induced apoptotic cell death in cancer cells.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
N-Acetilgalactosaminiltransferases
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Apoptose
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Diterpenos do Tipo Caurano
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Proteínas Reguladoras de Apoptose
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Ligante Indutor de Apoptose Relacionado a TNF
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Receptores do Ligante Indutor de Apoptose Relacionado a TNF
Limite:
Humans
Idioma:
En
Revista:
Biochimie
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Coréia do Sul