Bioinspired Core-Shell Nanoparticles for Hydrophobic Drug Delivery.
Angew Chem Int Ed Engl
; 58(40): 14357-14364, 2019 10 01.
Article
em En
| MEDLINE
| ID: mdl-31364258
ABSTRACT
A large range of nanoparticles have been developed to encapsulate hydrophobic drugs. However, drug loading is usually less than 10 % or even 1 %. Now, core-shell nanoparticles are fabricated having exceptionally high drug loading up to 65 % (drug weight/the total weight of drug-loaded nanoparticles) and high encapsulation efficiencies (>99 %) based on modular biomolecule templating. Bifunctional amphiphilic peptides are designed to not only stabilize hydrophobic drug nanoparticles but also induce biosilicification at the nanodrug particle surface thus forming drug-core silica-shell nanocomposites. This platform technology is highly versatile for encapsulating various hydrophobic cargos. Furthermore, the high drug loading nanoparticles lead to better inâ
vitro cytotoxic effects and inâ
vivo suppression of tumor growth, highlighting the significance of using high drug-loading nanoparticles.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Sistemas de Liberação de Medicamentos
/
Curcumina
/
Nanopartículas
/
Antineoplásicos
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Austrália