Fabrication and characterization of glimepiride nanosuspension by ultrasonication-assisted precipitation for improvement of oral bioavailability and in vitro &#945;-glucosidase inhibition.

Rahim, Haroon; Sadiq, Abdul; Khan, Shahzeb; Amin, Fazli; Ullah, Riaz; Shahat, Abdelaaty A; Mahmood, Hafiz Majid

Fabrication and characterization of glimepiride nanosuspension by ultrasonication-assisted precipitation for improvement of oral bioavailability and in vitro α-glucosidase inhibition.

Rahim, Haroon; Sadiq, Abdul; Khan, Shahzeb; Amin, Fazli; Ullah, Riaz; Shahat, Abdelaaty A; Mahmood, Hafiz Majid.

Afiliação

Rahim H; Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Khyber Pakhtunkhwa, 25000, Pakistan.
Sadiq A; Department of Pharmacy, University of Malakand, Chakdara, Khyber Pakhtunkhwa, 18800, Pakistan.
Khan S; Department of Pharmacy, University of Malakand, Chakdara, Khyber Pakhtunkhwa, 18800, Pakistan.
Amin F; Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban, 4000, South Africa.
Ullah R; Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA.
Shahat AA; Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Khyber Pakhtunkhwa, 25000, Pakistan.
Mahmood HM; Department of Pharmacognosy (MAPPRC), College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Int J Nanomedicine ; 14: 6287-6296, 2019.

Article em En | MEDLINE | ID: mdl-31496686

Assuntos

Precipitação Química; Inibidores de Glicosídeo Hidrolases/farmacologia; Nanopartículas/química; Compostos de Sulfonilureia/farmacologia; Ultrassom; alfa-Glucosidases/metabolismo; Administração Oral; Animais; Disponibilidade Biológica; Varredura Diferencial de Calorimetria; Derivados da Hipromelose/química; Nanopartículas/ultraestrutura; Tamanho da Partícula; Coelhos; Solubilidade; Compostos de Sulfonilureia/administração & dosagem; Compostos de Sulfonilureia/química; Compostos de Sulfonilureia/farmacocinética; Suspensões; Difração de Raios X

Palavras-chave

boosted bioavailability; ï»¿glimepiride nanosuspension; ï»¿precipitationultrasonication approach

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Precipitação Química / Compostos de Sulfonilureia / Ultrassom / Alfa-Glucosidases / Nanopartículas / Inibidores de Glicosídeo Hidrolases Limite: Animals Idioma: En Revista: Int J Nanomedicine Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Paquistão

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