A novel Nanoformulation Development of Eugenol and their treatment in inflammation and periodontitis.
Saudi Pharm J
; 27(6): 778-790, 2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-31516320
ABSTRACT
OBJECTIVE:
To prepare a novel nanoemulsion- Carbopol® 934 gel for Eugenol, in order to prevent the periodontitis. MATERIAL ANDMETHODS:
Spontaneous emulsification method was used for the preparation of nanoemulsion in which it contain Eugenol (oil phase), Tween-80 (surfactant), and PEG (co-surfactant). To the development of best nanoemulsion, three-factor three-level central composite design was used in which %oil; %Smix and % water were optimized as independent variables. An optimized-nanoemulsion were converted to nanoemulsion-Carbopol® 934 gel.RESULTS:
5.5% oil, 35.5% Smix and 59.0% water were optimized as independent and dependent variables. Finally dependent variables optimized as a particle size (nm), PDI and %transmittance were observed 79.92⯱â¯6.33â¯nm, 0.229⯱â¯0.019, and 98.88⯱â¯1.31% respectively. The values of final results for dependent variables like particle size (nm), PDI and % transmittance were evaluated as 79.92⯱â¯6.33â¯nm, 0.229⯱â¯0.019, and 98.88⯱â¯1.31%, respectively. TEM and SEM showed a spherical shape of developed nanoemulsion with refractive index (1.63⯱â¯0.038), zeta potential (-19.16⯱â¯0.11), pH (7.4⯱â¯0.06), viscosity (34.28⯱â¯6 cp), and drug content of 98.8⯱â¯0.09%. After that a final optimized EUG-NE-Gel was assessed on the basis of their pH measurement, drug content, syringeability, and mucoadhesion on the goat buccal mucosa. Optimized EUG-NE-Gel (Tween-80 and Carbopol® 934 used) showed the results, to improve the periodontal drug delivery of EUG in future.CONCLUSION:
EUG-NE-Gel showed a significant role in anti-inflammatory activity, analgesic, and anesthetic, antibacterial, and treatment of periodontal disease.
Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Saudi Pharm J
Ano de publicação:
2019
Tipo de documento:
Article