The <i>In Vitro</i> Functional Impairment of Thyroid Hormone Receptor Alpha 1 Isoform Mutants Is Mainly Dictated by Reduced Ligand Sensitivity.

Wejaphikul, Karn; van Gucht, Anja L M; Groeneweg, Stefan; Visser, W Edward; Visser, Theo J; Peeters, Robin P; Meima, Marcel E

The In Vitro Functional Impairment of Thyroid Hormone Receptor Alpha 1 Isoform Mutants Is Mainly Dictated by Reduced Ligand Sensitivity.

Wejaphikul, Karn; van Gucht, Anja L M; Groeneweg, Stefan; Visser, W Edward; Visser, Theo J; Peeters, Robin P; Meima, Marcel E.

Afiliação

Wejaphikul K; Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, The Netherlands.
van Gucht ALM; Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Groeneweg S; Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, The Netherlands.
Visser WE; Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, The Netherlands.
Visser TJ; Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, The Netherlands.
Peeters RP; Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, The Netherlands.
Meima ME; Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, The Netherlands.

Thyroid ; 29(12): 1834-1842, 2019 12.

Article em En | MEDLINE | ID: mdl-31530256

Assuntos

Mutação/genética; Receptores alfa dos Hormônios Tireóideos/genética; Receptores alfa dos Hormônios Tireóideos/metabolismo; Linhagem Celular Tumoral; Simulação por Computador; Humanos; Ligantes; Modelos Moleculares; Correpressor 1 de Receptor Nuclear/genética; Coativador 1 de Receptor Nuclear/genética; Ligação Proteica; Elementos de Resposta; Transcrição Gênica; Tri-Iodotironina/metabolismo

Palavras-chave

coregulatory proteins; receptor mutation; resistance to thyroid hormone; thyroid hormone action; thyroid hormone receptor; thyroid hormone response elements

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores alfa dos Hormônios Tireóideos / Mutação Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Thyroid Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Holanda

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